Patent scenario of COVID-19 vaccines: A promising analysis and review of innovation and development

Coronavirus disease 2019 (COVID-19), a highly contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a devastating effect on world demographics and emerged as a significant global health emergency since the influenza pandemic of 1918. It emphasized the significance of international cooperation in battling SARS-CoV-2 efficiently ever since the discovery and publication of the virus's genome in January 2020. The world took significant steps to combat the disease, ranging from increasing personal protective equipment production and emphasizing the importance of social distancing/masking to the Emergency Use Authorization of remdesivir/therapeutic antibodies. Despite significant advances in clinical research that have led to a better understanding of SARS-CoV-2 and COVID-19 management, limiting the virus's and its variants' spread, has become a growing concern as SARS-CoV-2 continues to cause chaos around the world, with many countries experiencing a second or third wave of outbreaks attributed primarily due to the emergence of mutant virus variants. Considering the potential threat of this global outbreak, scientist and medics have rushed to identify possible treatment regimens and effective therapeutic drugs and vaccinations. As a matter of fact, several COVID-19 vaccines candidate have been researched, created, tested, and reviewed at a breakneck pace. Finding patents, examining relevant patents for current research activities and assessing them plays a key part for the best possible research and development before establishing and executing a trading strategy, especially with recent technology advancements. Therefore, to support current research and development we have evaluated patents relevant to various COVID-19 vaccine technology platforms. The aim of the present research work is to map the existing work through an analysis of patent literature in the field of Coronaviruses, particularly COVID-19 vaccines which will subsequently help the organization launch campaigns, as well as academics and research-driven institutions with the aid of patent literature information for a range of initiatives to combat this circulating demon.

SARS-CoV-2 Antibody and T Cell Response After Vaccination with or without Intensified Immunosuppression Among Pediatric Renal Transplant Recipients

Purpose: Recent data has shown poor antibody response to SARS-CoV-2 vaccination among adult kidney transplant (tx) recipients, with seroconversion ranging between 22%-58% after two mRNA vaccine doses. Here, we evaluated the antibody and T cell response to SARS-CoV-2 vaccination and evaluate the effects of intensified immunosuppression on such response in pediatric (ped) kidney tx recipients. Method(s): Between April and November 2021, 31 ped renal tx patients (pts)aged 13-22 years old had SARS-CoV-2 spike IgG assessment after receiving 2 doses of SARS-CoV-2 mRNA or 1 dose of viral vector vaccine. Pts were evaluated by their level of immunosuppression: A) standard immunosuppression (tacrolimus, mycophenolate mofetil +/- steroids) or B) intensified immunosuppression (standard immunosuppression + solumedrol pulse, IVIG, rituximab, and/or tocilizumab within 11 months prior to and up to 5 months after SARS-CoV-2 vaccination). A subgroup of 18 pts had SARS-CoV-2 Tc assessment post-vaccination. Result(s): 23 of 31 (74.2%) pts seroconverted at a median assessment time of 83 days (IQR 43-124) post-vaccination. There was no difference in the use of steroid-based or steroid-free immunosuppression between the two groups or the type of vaccine received (Table 1). 15 of 17 (88.2%) of those who received standard immunosuppression seroconverted post-vaccination compared to 8 of 14 (57.1%) in those who received intensified immunosuppression (Table 1;p = 0.10). In a subgroup of pts who had SARS-CoV-2 spike-specific Tc testing, 7 of 7 (100%) in the standard immunosuppression group had positive Tc compared to 7 of 11 (63.6%) in the intensified immunosuppression group (Table 1, p = 0.12). There was no leukopenia or difference in the WBC count in either group at the time of Tc testing (Table 1;p = 0.97). No pts developed symptomatic SARS-CoV-2 infection. Conclusion(s): Ped renal tx recipients appear to have higher rates of seroconversion after the standard 2-dose mRNA or 1-dose viral vector SARS-CoV-2 vaccination compared to adult renal tx recipients. The intensified immunosuppression group appears to have a trend towards lower SARS-CoV-2 spike IgG and Tc conversion, however, results are limited by the small sample size. Larger studies are needed to better understand the humoral and cellular response to SARS-CoV-2 vaccination in this group. (Figure Presented).

A RARE CASE OF ACUTE PULMONARY HISTOPLASMOSIS FOLLOWING COVID-19 INFECTION

SESSION TITLE: COVID-19 Case Report Posters 3 SESSION TYPE: Case Report Posters PRESENTED ON: 10/19/2022 12:45 pm - 01:45 pm INTRODUCTION: The most reported fungal infections in patients with COVID-19 include aspergillosis, invasive candidiasis, and mucormycosis. We hereby present a case of a male who developed acute pulmonary histoplasmosis (APH) after COVID-19 infection. CASE PRESENTATION: 51-year-old male with PMHx of COVID-19 infection 3 weeks ago presenting with worsening shortness of breath. Patient had a complicated hospital course with COVID-19 treated with high doses of methylprednisolone. Patient was local to Arizona and lived on a ranch with livestock. CT chest suggestive of multilobar pneumonia and bilateral pleural effusions (Image 1). Coccidiomycosis serology came back negative. Urinary Histoplasma galactomannan antigen came back positive. The diagnosis of APH after COVID-19 infection was established. Patient was started on voriconazole. His symptoms significantly improved. Patient was discharged to skilled nursing facility with outpatient infectious disease follow-up. DISCUSSION: The current literature on APH in the setting of COVID-19 infection is limited. The few proposed mechanisms are: 1. Liberal use of high dose steroids in COVID-19 leading to reactivation of latent H. Capsulatum. 2. Systemic inflammation in COVID-19 causes interstitial lung damage permitting conidia to proliferate leading to acute infection. The Histoplasma urine antigen test is highly sensitive in the diagnosis of APH, especially in immunocompromised patients like our patient. With this case we would like to increase awareness of the possibility of rare fungal infections like APH in patients with COVID-19, as timely diagnosis and appropriate management can lead to improved outcomes. CONCLUSIONS: Rare fungal infections following COVID-19 have been documented and timely diagnosis and management are imperative to improve patient outcomes. Reference #1: Macedo, Priscila M, et al. APH following COVID-19. Case Report J.Fungi 2021 DISCLOSURES: No relevant relationships by Ali Raja no disclosure on file for Yamin Saddouk;No relevant relationships by Parita Soni No relevant relationships by Lyndie Wilkins Parker

BULLOUS/CYSTIC LUNG CHANGES: RARE RADIOGRAPHIC MANIFESTATIONS AFTER COVID-19

SESSION TITLE: Pathologies of the Post-COVID-19 World SESSION TYPE: Rapid Fire Case Reports PRESENTED ON: 10/18/2022 10:15 am - 11:10 am INTRODUCTION: Chest radiograph has played a vital role during the Covid 19 pandemic. It has allowed early diagnosis and to assess the severity of infection. Bullous lung lesions associated with Covid 19 are of the rare occurrence. So far very minimal literature is available on the Cystic/Bullous lung changes after Covid 19. We hereby present a case of a young patient with Covid 19 who developed cystic and bullous lung changes. CASE PRESENTATION: 44-year-old man nonsmoker with no significant PMHx admitted to hospital with Covid 19 pneumonia. Patient was extremely hypoxic with SPO2 81% upon arrival to the ER. Which improved significantly after supplemental oxygen. Chest x-ray was suggestive of bilateral peripheral airspace opacities. CT Angio chest showed diffuse ground glass opacification and bilateral pulmonary embolism. Patient received Dexamethasone, Remdesivir and Tocilizumab. Patient improved and was discharged home with oxygen and Apixaban. Repeat CT scan was performed after 2 months was suggestive of evolving cystic and bullous lesions (image 1). Pulmonary function test was suggestive of moderate restrictive pattern with mildly decreased DLCO. Family history was not significant. Detailed workup for cystic lung disease including bronchoscopy with bronchoalveolar lavage and bronchial brushing came back negative. Given the peripheral nature of these lesions, patient was advised to avoid strenuous activities to avoid complications like pneumothorax/pneumomediastinum. Patient continued to do well, Bullous lesions continued to improve on serial CT scans, without need for any surgical interventions. DISCUSSION: The common radiographic manifestations of Covid 19 are consolidation, ground glass opacification, mosaic attenuation, honeycombing, reticulation and air bronchograms (1). Atypical radiographic manifestation of Covid 19 pneumonia places a new challenge for the ongoing Covid 19 pandemic. The exact pathophysiology behind cystic/bullous lung lesions after Covid 19 is unclear however, it is likely from parenchymal damage, pulmonary fibrosis leading to decreased compliance versus direct lung injury by the virus. More research is warranted to identify the actual prevalence, risk factors and long-term clinical outcomes in such patients. Our patient remained clinically stable and was taken off oxygen within a few weeks upon hospital discharge and did not require any surgical intervention. CONCLUSIONS: With this case, we would like to add the following to the current literature: 1. Bullous/Cystic lung changes is one of rare post COVID 19 Sequela 2. Early detection and timely management can prevent life-threatening complications like pneumothorax/pneumomediastinum 3. Covid 19 should be considered as one of the differentials when dealing with Bullous/Cystic lung disease Reference #1: 1. Pednekar,P et al. doi.org/10.3389/fmed.2021.770778 DISCLOSURES: No relevant relationships by Belice Cabrera No relevant relationships by Belice Cabrera No relevant relationships by Parita Soni

Patent Landscape of COVID-19 Innovations: A Comprehensive Review

The COVID-19 pandemic save a stringent upshot on the lives of human. The people are running in race to save themselves and the race is still on. COVID emergency has not only retarded the health of the society but also made it face the economic downfall in a severe manner. The scientists and the data analyst gave their predictions for the additional wave of infection, thus stating COVID appropriate behaviour as the medicine for the time. This health calamity provides an opportunity for cross-sector partnership of technology and science as to keep the battle fight strong, finding new roads leading to fresh solutions in health care and innovations. There is a requirement of asystematic approach for accessing the patent literature that is already available to form a research platform for further advancements. The study serves a general view of the search strategy and approach, categorization of search, database set used, websites, novelty, derivation of innovation, field of work, and the investigational dataset regarding the COVID-19 patent literature under the category of diagnosis, sanitization, personal protection and vaccine development available from December 2019 to June 2021. The patent literature provides us with the knowledge which innovation is riled fust for patent and] published documents which can be found in the database search, thus deriving the ideologies as a supplementary guidance for the advancement of innovations. Evidently, it can be concluded that our research and report can be helpful in drawing some innovative outlines with industrial applications or some others which require further interpretation with more concern. © 2022, National Institute of Science Communication and Information Resources. All rights reserved.

Promoting Childhood and Adolescent Cardiovascular Health: Analyzing School Meal Nutrition

Background: Schools play a vital role in childhood nutrition. Months into the COVID-19 pandemic, 21 million free meals were distributed by Chicago Public Schools (CPS). Cardiovascular (CV) risk factors begin in childhood and school meals establish healthy eating patterns. To our knowledge, school meal nutrition has not been studied from a CV disease prevention perspective. Guidelines published by the National Heart, Lung, and Blood Institute (NHLBI) in 2012 strongly recommend that 2-21-yearolds consume <30% of calories/day from fat, <10% of calories/day from saturated fat, and <300 mg of cholesterol/day to promote CV health in adolescence. As CPS currently follows USDA nutrition guidelines, we sought to determine the alignment of school meals for K-8th graders with NHLBI recommendations. Methods: May and June 2021 CPS breakfasts and lunches were analyzed. Menus were obtained from the CPS website and nutrition information from a school nutritionist. Total breakfast and lunch calories, calories from fat, calories from saturated fat, and mg of cholesterol were recorded. The percent of daily caloric intake from fat and saturated fat was calculated. Days that cholesterol content exceeded 200 mg (2/3 of daily recommended) were analyzed as we examined 2/3 of daily meals. The effect of milk (skim, chocolate skim, or 1%) was considered. The number of meals meeting NHLBI guidelines were counted, and the percentage of meals meeting standards were calculated with 95% confidence intervals. Results: CPS meals met the standards for total fat, saturated fat, and cholesterol on 62%, 60%, and 78% of days, respectively with median values meeting NHLBI standards. When factoring milk consumption, skim and chocolate milk respectively add 85 and 115 calories with no fat and 5 mg cholesterol. Both of these milk choices improve compliance with total and saturated fat standards while having a negligible impact on the cholesterol standard. 1% milk adds 105 calories at the expense of 27 calories of fat, 18 calories of saturated fat, and 15 mg of cholesterol. This milk has minimal impact on the total fat standard and total cholesterol standards but a negative impact on the saturated fat standard. Cholesterol results are greatly impacted by eggs. On all the days where total cholesterol exceeded 200 mg, hardboiled eggs were served at breakfast. Conclusion: Over the last several decades, the nutritional quality of school meals has vastly improved. Specifically, CPS is a leader in nutrition standards and has made monumental strides to improve school meals. As a program federally funded by the National School Lunch Program, CPS represents many other qualifying schools. While CPS currently exceeds the USDA guidelines it is expected to comply with, the rates of compliance with NHLBI guidelines suggest there is room for improvement. Current guidelines may want to consider implementing standards specific to CV health promotion. (Left). Proportion of active IEP initiated and/or managed by RHCSP education liaisons by diagnosis. Values listed represent N, percentage (%). Figure 1b (Right). Proportion of active 504 initiated and/or managed by RHCSP education liaisons by diagnosis. Values listed represent N, percentage (%).

Comparative analysis of the diagnostic performance of five commercial COVID-19 qRT PCR kits used in India.

To meet the unprecedented requirement of diagnostic testing for SARS-CoV-2, a large number of diagnostic kits were authorized by concerned authorities for diagnostic use within a short period of time during the initial phases of the ongoing pandemic. We undertook this study to evaluate the inter-test agreement and other key operational features of 5 such commercial kits that have been extensively used in India for routine diagnostic testing for COVID-19. The five commercial kits were evaluated, using a panel of positive and negative respiratory samples, considering the kit provided by National Institute of Virology, Indian Council of Medical Research (2019-nCoV Kit) as the reference. The positive panel comprised of individuals who fulfilled the 3 criteria of being clinically symptomatic, having history of contact with diagnosed cases and testing positive in the reference kit. The negative panel included both healthy and disease controls, the latter being drawn from individuals diagnosed with other respiratory viral infections. The same protocol of sample collection, same RNA extraction kit and same RT-PCR instrument were used for all the kits. Clinical samples were collected from a panel of 92 cases and 60 control patients, who fulfilled our inclusion criteria. The control group included equal number of healthy individuals and patients infected with other respiratory viruses (n = 30, in each group). We observed varying sensitivity and specificity among the evaluated kits, with LabGun COVID-19 RT-PCR kit showing the highest sensitivity and specificity (94% and 100% respectively), followed by TaqPath COVID-19 Combo and Allplex 2019-nCoV assays. The extent of inter-test agreement was not associated with viral loads of the samples. Poor correlation was observed between Ct values of the same genes amplified using different kits. Our findings reveal the presence of wide heterogeneity and sub-optimal inter-test agreement in the diagnostic performance of the evaluated kits and hint at the need of adopting stringent standards for fulfilling the quality assurance requirements of the COVID-19 diagnostic process.

Single center experience on SARS-CoV-2 testing of symptomatic and asymptomatic pediatric kidney transplant recipients

Purpose: As of late November 2020, there have been 61.5 million cases of SARSCoV- 2 (COVID-19) worldwide resulting in 1.44 million deaths. Despite the outstanding number of cases there is limited data on the incidence of SARS-CoV-2 infection, both symptomatic and asymptomatic, among pediatric (ped) kidney transplant (KTx) patients (pts) and their outcomes. Methods: Between March and November 2020, 33 SARS-CoV-2 RNA RT-PCR tests were performed among 23 ped KTx pts who were maintained on mycophenolate mofetil, tacrolimus, +/- steroids. Pts were tested for SARS-CoV-2 if they had any COVID-19 symptoms, had positive COVID-19 contact, or needed SARS-CoV-2 testing for admission to the hospital or for pre-procedural clearance. No pts were tested more than once during each encounter. Results: Of the 33 SARS-CoV-2 tests performed, 7 (21.2%) were due to pts having one or several COVID-19-like symptoms, while 26 (78.8%) were for pts who had positive COVID-19 contact or needed SARS-CoV-2 testing for admission to the hospital or for pre-procedural clearance. Of the 33 tests performed, there were 3 (9.1%) confirmed cases of COVID-19. Two of the 3 SARS-CoV-2 positive cases had symptoms consistent with infection, compared to one asymptomatic case (p = 0.11). The two positive cases with symptoms were on steroid-free immunosuppression, had estimated GFR (eGFR) of 101 and 60 ml/min/1.73m2, and were 0.9 and 3.1 years post-Tx, respectively. The one asymptomatic case was on steroid-based immunosuppression, had eGFR 85, and was 0.9 years post-Tx. No pts who tested positive for SARS-CoV-2 required hospitalizations. Five of the 7 pts (71.4%) with symptoms consistent with COVID-19 were eventually diagnosed with a different infection (bacterial and/or viral) and all required admission for management. Conclusions: There is a low rate of asymptomatic SARS-CoV-2 (COVID-19) infection among our ped KTx cohort. When infected with SARS-CoV-2, ped KTx pts tend to present with minimal symptoms. In this small cohort, there appears to be no correlation between the time since Tx, eGFR, and the maintenance immunosuppression in relation to whether or not pts were more likely to have symptoms or have more severe disease if infected with SARS-CoV-2. Ped KTx pts with symptoms concerning for COVID-19 with clinical indications for admission were more likely to have alternative diagnoses. Larger studies are needed to understand the prevalence and impact of SARS-CoV-2 infection in the ped KTx population.

Association of depression with il-6 and crp levels among covid recovered patients: A hospital based case control study

Introduction: Depression has been reported in patients suffered from COVID 19 (corona virus disease). Inflammatory markers like IL-6 and CRP have been also found raised in COVID 19 patients. Aim: The objective of present study was to find out the association of serum IL-6 and CRP levels with depression in COVID 19 patients discharged from hospital. Materials and Methodology: This Case control study included 30 patients of depression attending post COVID OPD after getting discharged from hospital and 30 post COVID patients without depression. Depression was diagnosed using PHQ-9 scores. A cutoff value of 10 was taken to diagnose depression upon PHQ-9 scale. Both groups were compared in relation to socio-demographic variables, serum IL-6 & CRP levels and other clinical variables. Results: Serum IL-6 and CRP levels were significantly higher in post COVID patients with depression (IL-6=39.71 ± 46.39, CRP=43.66 ± 31.78) than those without depression (IL-6= 13.42 ± 18.98, CRP= 21.02 ± 25.36). Hospital stay was also greater in post COVID patients with depression. Conclusion: Post COVID depression was significantly associated with IL-6 and CRP levels. Patients with raised level of these markers could be screened for early identification of depression and counseled preferentially for prevention of depression during post COVID period.

Analysis of covid-19 pandemic impact

A couple of months prior, we were carrying on with a totally unique life, not knowing how rapidly things would change. The Coronavirus is an overall disturbing impact that has compelled us all to get together and endeavor to stop it. This research is about building a web site that offer useful data to help fight against Covid-19 pandemic. This application is for everyone who need to consider the current situation concerning this pandemic time in general over world and if a customer needs to search for information about Covid-19 cases in their domain. For using this application one just need to have a latest cell phone or laptop with web access. The communicated inspiration driving this application is to spread experience with Covid-19. With informing system, it endeavors to choose the peril on the off chance that one has been very nearly a Covid-19 debased individual, by investigating an informational collection of identified cases through India. Using territory information, it chooses if the region one is in has a spot with one of the contaminated zones reliant upon the information accessible.

Pneumomediastinum in vaping induced lung injury

Introduction: Electronic cigarettes and vaping associated lung injury (EVALI) is a new and emerging disease in the recent years. The patients who vape have Valsalva maneuver due to forceful exhalation from coughing which increases their risk for spontaneous pneumomediastinum (SPM). We present a case of 18 year-old man who has significant history of vaping and presents with SPM. Case Presentation: 18 Year old man with no medical history presented with cough, wheezing and shortness of breath for three weeks. He complained of pleuritic chest pain especially with coughing. He denied any fever, chills, nausea, vomiting or abdominal pain. He denied COVID-19 exposure or sick contacts. In the ER his Spo2 was 88% on ambient air so he was placed on O2 via nonrebreather mask with Spo2 of 94%. He denied smoking but endorsed to extensive daily vaping which resulted in severe coughing spasms. Complete blood count (CBC) showed leukocytosis of 19.2 K/UL. His COVID PCR was negative and COVID IgG was non-reactive and urine toxicology screen was negative for any illicit substances. CXR showed multiple bilateral reticular opacities and CT Chest showed multiple bilateral discrete consolidation in the central portion of both lungs (Fig. 1) and significant pneumomediastinum (PM). PM was thought to be secondary to coughing. He was started on methylprednisone 40 mg Q12hrs and oxygen therapy was continued with the goal to keep SPo2 >90%. He was taken off oxygen after 48 hours steroid treatment. His repeat imaging showed significant improvement of PM and patient was discharged with follow up. Discussion: The incidence of EVALI has increased especially among teenagers. Some of the known complications associated with vaping are atelectasis and pneumonia but PM is rare. The mechanism of PM can be explained by two hypotheses: 1. intrathoracic pressure from forceful inhalation during vaping leading to compensatory physiological exhalation against closed glottis resulting in alveolar damage. 2. Forceful inhalation through narrow lumen of vaping devise leading to Mullen's mechanism causing alveolar damage. This alveolar rupture leads air to dissect along peribronchovascular interstitial sheaths, visceral pleura, and into mediastinum (Macklin's effect) [1]. PM is usually treated with supportive without any significant adverse effects. From literature review only few cases have been reported describing EVALI related penumomediastim but physicians should be aware of the potential complications to educate their patients.

An in-house lateral flow immunoassay: Point of care test for covid-19 IGG/IGM antibodies detection

Aims & Objectives: The ''gold-standard'' test for the diagnosis of COVID-19 is real time PCR, not all cases with mild symptoms or asymptomatic cases are subjected to RT-PCR analysis. It is also not practically feasible in a country like India, considering the cost, number of subjects to be screened and the required technical expertise. The sero-conversion in case of COVID-19 generally occurs from 4th or 5th day after the onset of symptoms.To develop a cost-effective, rapid kit for detection of IgG and IgM antibodies to COVID-19 using gold nanoparticle labeled antigen/antibody. Patients/Materials & Methods: Standardization of the LFIA antibody test involved many different experiments. Different size of gold nanoparticles were prepared and used. These GNPs were then adjusted to different pH for optimal binding: pH 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0 using different buffers(PBS, Borate, carbonate, etc.). The pore size of membranes play an important role and thus different pore size membranes were use (5,8,10,12,15 lm). Reaction temperature of 37C and RT were checked for maximum sensitivity. Different concentrations of the proteins ranging from 0.4 mg/ml to 100 mg/ml were tried. For the same, serum samples of 15 patients who were COVID-19 RT PCR positive having symptoms of fever, sore throat, etc. were collected between 7 to 14 days post symptoms and of 40 patients at least 28 days post symptoms. All the results were cross checked and compared with ICMR validated Rapid tests and ELISAs for IgG and IgM. Results: Internal Validation: The results are in good accordance to ICMR validated Rapid tests and ELISAs where in ssensitivity of 89.6% and 91% were obtained for IgG and IgM respectively. External Validation. 1: ICMR-National Institute of Virology 200 kits were sent for validation, Sensitivity, Specificity and cross reactivity with real-time RT-PCR positive for influenza A (H1N1) pdm09, influenza A (H3N2), human coronavirus OC43, rhinovirus, respiratory syncytial virus, influenza B, parainfluenza type 4, hepatitis B virus, hepatitis C virus, etc. was done by ICMR -NIV. Sensitivity was 87.5% and 90% for IgG and IgM, respectively and specificity was 97.12 for both. 2: Rajiv Gandhi Centre for Biotechnology (RGCB)-DBT 300 kits were sent for validation. Sensitivity was 96% and 90.67% and specificity was 97.12 for IgG and IgM, respectively. The working cost is around 120Rs. The kit has now gone to the Technology transfer and commercialization department at ICMR, New Delhi. Discussion & Conclusion: The antibody diagnosis approach is important in COVID-19 epidemic to diagnose the asymptomatic cases, to assess the magnitude of infection as well as to assess the number of people who are protected from infection, though it is still not clear about the protective effect of these antibodies for repeated infection. The in-house kit was found to be highly sensitive and specific with the working cost being 100-120 Rs.

Sentiment Identification in COVID-19 Specific Tweets

In 2020, our world has been hit by a global pandemic of COVID-19, belonging to the family of Coronavirus. Due to the rapid increase in the infection and the death rate, people have started to develop mixed feelings regarding this situation. Therefore, in this study, our sole focus is to analyze the emotions expressed by people using social media such as Twitter etc. Accumulating and studying the concerning tweets will provide aid to elicitate the real emotions during this hard time. The goal of this study is to present a domain-specific approach to understand sentiments manifested within people around the globe regarding this situation. In order to attain this, corona-specific tweets are acquired from twitter platform. After gathering the tweets, they are labelled and a model is developed which is effective for detecting the actual sentiment behind a tweet related to COVID-19. The substantial assessments are performed in bi-class and multi-class setting over n-gram feature set along with cross-dataset evaluation of different machine learning techniques in order to develop the model. Our experiments reveal that the proposed model performs well in perceiving the perception of people about COVID-19 with a maximum accuracy of about 93%. © 2020 IEEE.